Smarter nucleic acid design with NucleoBench and AdaBeam (opens in new tab)

Google Research and Move37 Labs have introduced NucleoBench, a comprehensive open-source benchmark for nucleic acid design, alongside AdaBeam, a high-performing new optimization algorithm. While AI models have become highly proficient at predicting the biological properties of DNA and RNA, generating optimal sequences within massive search spaces—such as the $2 \times 10^{120}$ possible variations for a 5' UTR—remains a significant hurdle. By standardizing evaluation across 16 distinct biological tasks, this research identifies AdaBeam as a superior method that scales effectively to the large-scale models required for modern drug discovery. ## Standardizing the Optimization Pipeline The process of computational nucleic acid design typically follows a five-step workflow: data collection, training a predictive model, generating candidate sequences (the design step), wet-lab validation, and iterative retraining. NucleoBench focuses specifically on the design step, which has historically lacked standardized evaluation. * Most existing benchmarks rely on decades-old methods like simulated annealing or vanilla genetic algorithms. * Traditional algorithms often treat predictive models as "black boxes," failing to leverage internal model data to guide the search. * The vastness of genomic search spaces makes brute-force optimization impossible, necessitating more intelligent, model-aware generation strategies. ## The NucleoBench Framework NucleoBench is the first large-scale benchmark designed to compare gradient-free and gradient-based design algorithms under identical conditions. The framework encompasses over 400,000 experiments to ensure statistical rigor across diverse biological challenges. * **Algorithm Categories**: It compares gradient-free methods (like directed evolution), which are simple but ignore model internals, against gradient-based methods (like FastSeqProp), which use the model’s internal "direction of steepest improvement" to find better sequences. * **Task Diversity**: The 16 tasks include controlling gene expression in specific cell types (liver or neuronal), maximizing transcription factor binding, and improving chromatin accessibility. * **Scale**: The benchmark includes long-range DNA sequence challenges using large-scale models like Enformer, which are computationally demanding but critical for understanding complex genomic interactions. ## AdaBeam’s Hybrid Optimization Performance Drawing on insights from the NucleoBench evaluation, the researchers developed AdaBeam, a hybrid algorithm that combines the strengths of various optimization strategies. * **Success Rate**: AdaBeam outperformed existing algorithms on 11 of the 16 tasks in the benchmark. * **Efficiency and Scaling**: Unlike many gradient-based methods that struggle with computational overhead, AdaBeam demonstrates superior scaling properties as sequences become longer and predictive models grow in complexity. * **Methodology**: It functions as a hybrid approach, using sophisticated search techniques to navigate the sequence space more effectively than "vanilla" algorithms developed before the era of deep learning. The researchers have made AdaBeam and the NucleoBench repository freely available to the scientific community. By providing a standardized environment for testing, they aim to accelerate the development of next-generation treatments, including more stable mRNA vaccines and precise CRISPR gene therapies.

Speculative cascades — A hybrid approach for smarter, faster LLM inference (opens in new tab)

Speculative cascades represent a hybrid inference method that integrates the cost-efficiency of model cascades with the latency-reducing benefits of speculative decoding. By utilizing a smaller drafter model to generate token sequences that are verified in parallel by a larger expert model, this approach allows for high-speed generation while maintaining flexible quality standards. The result is a system that achieves superior cost-quality trade-offs and higher speed-ups than either traditional cascading or standard speculative decoding alone. ### Limitations of Cascades and Speculative Decoding * **Sequential Bottlenecks in Cascades:** Traditional cascades use a deferral rule to decide if a small model can handle a prompt. If the small model is not confident, the system waits for it to finish before starting the large model from scratch, wasting significant time. * **Strict Matching in Speculative Decoding:** This method requires the large model to verify the small model’s tokens. Even if the small model produces a factually correct and high-quality response, the large model will reject the entire draft if the tokens do not match its own preferred output exactly. * **Trade-off Divergence:** Cascades prioritize reducing computational costs but suffer from latency when deferring, while speculative decoding prioritizes speed but often performs redundant work because it mandates identical output to the larger model. ### The Speculative Cascades Mechanism * **Parallel Verification with Deferral:** Speculative cascades use the parallel processing of speculative decoding but introduce a flexible decision rule. The system can choose to accept the smaller model’s draft even if it differs from the larger model’s prediction, provided it meets a confidence threshold. * **Flexible Token Matching:** Unlike standard speculative decoding, which often relies on strict token-by-token matching, speculative cascades allow for "probabilistic matches" or quality-based acceptance to prevent unnecessary rejections. * **Resource Optimization:** By strategically deferring to the smaller model for certain segments of the generation, the system reduces the total work required from the expensive expert model without losing the speed of parallel execution. ### Empirical Results and Performance * **Model Testing:** The approach was validated using Gemma and T5 models across diverse language tasks, including reasoning, coding, translation, and question answering. * **Superior Trade-offs:** Testing showed that speculative cascades consistently outperformed baselines in cost-quality metrics, providing faster inference without the strict "all-or-nothing" quality constraints of speculative decoding. * **Task Versatility:** The hybrid method proved effective across both creative tasks (like summarization) and factual tasks (like math or coding), where different levels of "correctness" are acceptable. Speculative cascades offer a practical path for scaling LLM deployments by balancing the high cost of large models with the need for low-latency user experiences. Developers looking to optimize inference should consider this hybrid approach to capture the efficiency of small models while retaining the oversight of larger, more capable ones.

Accelerating scientific discovery with AI-powered empirical software (opens in new tab)

Google Research has introduced an AI-powered system designed to accelerate scientific discovery by automating the creation and optimization of "empirical software." By leveraging the Gemini model and tree search optimization, the system can propose, implement, and iteratively improve code for complex multidisciplinary challenges, achieving results that match or exceed human expert performance. This approach transforms scientific hypothesis evaluation from a months-long manual coding process into an automated search that can be completed in hours or days. ### The Concept of Empirical Software and Scorable Tasks * The system shifts focus from traditional functional correctness to "empirical software," where the primary objective is to maximize a predefined quality score. * It targets "scorable tasks," which are defined by a problem description, a specific scoring metric, and a dataset for training and validation. * This framework addresses the research bottleneck where scientists must manually test hundreds of models or parameters to achieve a breakthrough. ### System Architecture and Optimization Strategy * The engine takes a task description and optional context—such as ideas from scientific literature—as input to generate novel methodological concepts. * It utilizes a tree search strategy inspired by AlphaZero, employing an upper confidence bound to navigate and prioritize thousands of potential code variants. * The LLM acts as an iterative rewriter, refining executable code within a sandbox to continuously improve the performance score. * Outputs are designed to be fully verifiable, interpretable, and reproducible, providing scientists with the specific coded solutions used to reach a result. ### Demonstrated Performance Across Scientific Domains * The system was tested on six diverse benchmarks, including genomics, public health, geospatial analysis, neuroscience, and time-series forecasting. * In genomics, the system tackled the "batch integration" of single-cell RNA sequencing (scRNA-seq) data, a complex problem involving the removal of noise while preserving biological signals. * The AI discovered 40 novel methods that outperformed top expert-developed tools within the OpenProblems V2.0.0 batch integration benchmark. * Evaluation focused on advanced capabilities such as zero-shot generalization, high-dimensional signal processing, and uncertainty quantification. This system represents a significant shift toward "research engines" that participate actively in the scientific method through iterative experimentation. Scientists can utilize these tools to explore a much broader range of hypotheses than manual coding allows, potentially leading to faster breakthroughs in data-heavy fields like genomics and climate modeling.

Code Quality Improvement Techniques Part 19: Child Lock (opens in new tab)

The "child lock" technique focuses on improving code robustness by restricting the scope of what child classes can override in an inheritance hierarchy. By moving away from broad, overridable functions that rely on manual `super` calls, developers can prevent common implementation errors and ensure that core logic remains intact across all subclasses. This approach shifts the responsibility of maintaining the execution flow to the parent class, making the codebase more predictable and easier to maintain. ## Problems with Open Functions and Manual Super Calls Providing an `open` function in a parent class that requires child classes to call `super` creates several risks: * **Missing `super` calls:** If a developer forgets to call `super.bind()`, the essential logic in the parent class (such as updating headers or footers) is skipped, often leading to silent bugs that are difficult to track. * **Implicit requirements:** Relying on inline comments to tell developers they must override a function is brittle. If the method isn't `abstract`, the compiler cannot enforce that the child class implements necessary logic. * **Mismatched responsibilities:** When a single function handles both shared logic and specific implementations, the responsibility of the code becomes blurred, making it easier for child classes to introduce side effects or incorrect behavior. ## Implementing the "Child Lock" with Template Methods To resolve these issues, the post recommends a pattern often referred to as the Template Method pattern: * **Seal the execution flow:** Remove the `open` modifier from the primary entry point (e.g., the `bind` method). This prevents child classes from changing the overall sequence of operations. * **Separate concerns:** Move the customizable portion of the logic into a new `protected abstract` function. * **Enforced implementation:** Because the new function is `abstract`, the compiler forces every child class to provide an implementation, ensuring that specific logic is never accidentally omitted. * **Guaranteed execution:** The parent class calls the abstract method from within its non-overridable method, ensuring that shared logic (like UI updates) always runs regardless of how the child is implemented. ## Refining Overridability and Language Considerations Designing for inheritance requires careful control over how child classes interact with parent logic: * **Avoid "super" dependency:** Generally, if a child class must explicitly call a parent function to work correctly, the inheritance structure is too loose. Exceptions are usually limited to lifecycle methods like `onCreate` in Android or constructors/destructors. * **C++ Private Virtuals:** In C++, developers can use `private virtual` functions. These allow a parent class to define a rigid flow in a public method while still allowing subclasses to provide specific implementations for the private virtual components, even though the child cannot call those functions directly. To ensure long-term code quality, the range of overridability should be limited as much as possible. By narrowing the interface between parent and child classes, you create a more rigid "contract" that prevents accidental bugs and clarifies the intent of the code.

Extracting Trending Keywords from Open Chat Messages (opens in new tab)

To enhance user engagement on the LINE OpenChat main screen, LY Corporation developed a system to extract and surface "trending keywords" from real-time message data. By shifting focus from chat room recommendations to content-driven keyword clusters, the team addresses the lack of context in individual messages while providing a more dynamic discovery experience. This approach utilizes a combination of statistical Z-tests to identify frequency spikes and MinHash clustering to eliminate near-duplicate content, ensuring that the trending topics are both relevant and diverse. **The Shift from Chat Rooms to Content-Driven Recommendations** * Traditional recommendations focus on entire chat rooms, which often require significant user effort to investigate and evaluate. * Inspired by micro-blogging services, the team aimed to surface messages as individual content pieces to increase the "main screen visit" KPI. * Because individual chat messages are often fragmented or full of typos, the system groups them by keywords to create meaningful thematic content. **Statistical Detection of Trending Keywords** * Simple frequency counts are ineffective because they capture common social fillers like greetings or expressions of gratitude rather than actual trends. * Trends are defined as keywords showing a sharp increase in frequency compared to a baseline from seven days prior. * The system uses a Z-test for two-sample proportions to assign a score to each word, filtering for terms with at least a 30% frequency growth. * A seven-day comparison window is specifically used to suppress weekly cyclical noise (e.g., mentions of "weekend") and to capture topics whose popularity peaks over several consecutive days. **MinHash-based Message Deduplication** * Redundant messages, such as copy-pasted text, are removed prior to frequency aggregation to prevent skewed results and repetitive user experiences. * The system employs MinHash, a dimensionality reduction technique, to identify near-duplicate messages based on Jaccard similarity. * The process involves "shingling" messages into sets of tokens (primarily nouns) and generating $k$-length signatures; messages with identical signatures are clustered together. * To evaluate the efficiency of these clusters without high computational costs, the team developed a "SetDiv" (Set Diversity) metric that operates in linear time complexity. By combining Z-test statistical modeling with MinHash deduplication, this methodology successfully transforms fragmented chat data into a structured discovery layer. For developers working with high-volume social data, using a rolling weekly baseline and signature-based clustering offers a scalable way to surface high-velocity trends while filtering out both routine social noise and repetitive content.

Code Quality Improvement Techniques Part (opens in new tab)

Effective refactoring often fails when developers focus on the physical structure of code rather than its conceptual meaning. When nested loops for paged data are extracted into separate functions based solely on their technical boundaries, the resulting code can remain difficult to read and maintain. The article argues that true code quality is achieved by aligning function boundaries with logical units, such as abstracting data retrieval into sequences to flatten complex structures. ## Limitations of Naive Extraction - Traditional paged data processing often results in nested loops, where an outer `while` loop manages page indices and an inner `for` loop iterates through items in a chunk. - Simply extracting the inner loop into a private method like `saveMetadataInPage(page)` frequently fails to improve readability because it splits the conceptual task of "fetching all items" into two disconnected locations. - This "mechanical extraction" preserves the underlying implementation complexity, forcing the reader to track the state of pagination and loop conditions across multiple function calls. ## Refactoring Based on Conceptual Boundaries - A more effective approach identifies the high-level semantic units: "retrieving all items" and "processing each item." - In Kotlin, the pagination logic can be encapsulated within a `Sequence<Item>` using the `sequence` builder and `yieldAll` keywords. - By transforming the data source into a sequence, the consumer function can replace a nested loop with a single, clean `for` loop. - This abstraction allows the main business logic to focus on "what" is being done (saving metadata) while hiding the "how" (managing page indices and `hasNext` flags). ## Forest over Trees - When refactoring, developers should prioritize the "forest" (the relationship between operations) over the "trees" (individual functions). - This methodology is not limited to loops; it applies equally to nested conditional branches and complex data structures. - The goal should always be to ensure that the code reflects the meaning of the task, which often requires restructuring the data flow rather than just splitting existing blocks of code.

How Google’s AI can help transform health professions education (opens in new tab)

To address a projected global deficit of 11 million healthcare workers by 2030, Google Research is exploring how generative AI can provide personalized, competency-based education for medical professionals. By combining qualitative user-centered design with quantitative benchmarking of the pedagogically fine-tuned LearnLM model, researchers have demonstrated that AI can effectively mimic the behaviors of high-quality human tutors. The studies conclude that specialized models, now integrated into Gemini 2.5 Pro, can significantly enhance clinical reasoning and adapt to the individual learning styles of medical students. ## Learner-Centered Design and Participatory Research * Researchers conducted interdisciplinary co-design workshops featuring medical students, clinicians, and AI researchers to identify specific educational needs. * The team developed a rapid prototype of an AI tutor designed to guide learners through clinical reasoning exercises anchored in synthetic clinical vignettes. * Qualitative feedback from medical residents and students highlighted a demand for "preceptor-like" behaviors, such as the ability to manage cognitive load, provide constructive feedback, and encourage active reflection. * Analysis revealed that learners specifically value AI tools that can identify and bridge individual knowledge gaps rather than providing generic information. ## Quantitative Benchmarking via LearnLM * The study utilized LearnLM, a version of Gemini fine-tuned specifically for educational pedagogy, and compared its performance against Gemini 1.5 Pro. * Evaluations were conducted using 50 synthetic scenarios covering a spectrum of medical education, ranging from preclinical topics like platelet activation to clinical subjects such as neonatal jaundice. * Medical students engaged in 290 role-playing conversations, which were then evaluated based on four primary metrics: overall experience, meeting learning needs, enjoyability, and understandability. * Physician educators performed blinded reviews of conversation transcripts to assess whether the AI adhered to medical education standards and core competencies. ## Pedagogical Performance and Expert Evaluation * LearnLM was consistently rated higher than the base model by both students and educators, with experts noting it behaved "more like a very good human tutor." * The fine-tuned model demonstrated a superior ability to maintain a conversation plan and use grounding materials to provide accurate, context-aware instruction. * Findings suggest that pedagogical fine-tuning is essential for AI to move beyond simple fact-delivery and toward true interactive tutoring. * These specialized learning capabilities have been transitioned from the research phase into Gemini 2.5 Pro to support broader educational applications. By integrating these specialized AI behaviors into medical training pipelines, institutions can provide scalable, individualized support to students. The transition of LearnLM’s pedagogical features into Gemini 2.5 Pro provides a practical framework for developers to create tools that not only provide medical information but actively foster the critical thinking skills required for clinical practice.

A scalable framework for evaluating health language models (opens in new tab)

Researchers at Google have developed a scalable framework for evaluating health-focused language models by replacing subjective, high-complexity rubrics with granular, binary criteria. This "Adaptive Precise Boolean" approach addresses the high costs and low inter-rater reliability typically associated with expert-led evaluation in specialized medical domains. By dynamically filtering rubric questions based on context, the framework significantly improves both the speed and precision of model assessments. ## Limitations of Traditional Evaluation * Current evaluation practices for health LLMs rely heavily on human experts, making them cost-prohibitive and difficult to scale. * Standard tools, such as Likert scales (e.g., 1-5 ratings) or open-ended text, often lead to subjective interpretations and low inter-rater consistency. * Evaluating complex, personalized health data requires a level of detail that traditional broad-scale rubrics fail to capture accurately. ## Precise Boolean Rubrics * The framework "granularizes" complex evaluation targets into a larger set of focused, binary (Yes/No) questions. * This format reduces ambiguity by forcing raters to make definitive judgments on specific aspects of a model's response. * By removing the middle ground found in multi-point scales, the framework produces a more robust and actionable signal for programmatic model refinement. ## The Adaptive Filtering Mechanism * To prevent the high volume of binary questions from overwhelming human raters, the researchers introduced an "Adaptive" layer. * The framework uses the Gemini model as a zero-shot classifier to analyze the user query and LLM response, identifying only the most relevant rubric questions. * This data-driven adaptation ensures that human experts only spend time on pertinent criteria, resulting in "Human-Adaptive Precise Boolean" rubrics. ## Performance and Reliability Gains * The methodology was validated in the domain of metabolic health, covering topics like diabetes, obesity, and cardiovascular disease. * The Adaptive Precise Boolean approach reduced human evaluation time by over 50% compared to traditional Likert-scale methods. * Inter-rater reliability, measured through intra-class correlation coefficients (ICC), was significantly higher than the baseline, proving that simpler scoring can provide a higher quality signal. This framework demonstrates that breaking down complex medical evaluations into simple, machine-filtered binary questions is a more efficient path toward safe and accurate health AI. Organizations developing domain-specific models should consider adopting adaptive binary rubrics to balance the need for expert oversight with the requirements of large-scale model iteration.

From massive models to mobile magic: The tech behind YouTube real-time generative AI effects (opens in new tab)

YouTube has successfully deployed over 20 real-time generative AI effects by distilling the capabilities of massive cloud-based models into compact, mobile-ready architectures. By utilizing a "teacher-student" training paradigm, the system overcomes the computational bottlenecks of high-fidelity generative AI while ensuring the output remains responsive on mobile hardware. This approach allows for complex transformations, such as cartoon style transfer and makeup application, to run frame-by-frame on-device without sacrificing the user’s identity. ### Data Curation and Diversity * The foundation of the effects pipeline relies on high-quality, properly licensed face datasets. * Datasets are meticulously filtered to ensure a uniform distribution across different ages, genders, and skin tones. * The Monk Skin Tone Scale is used as a benchmark to ensure the effects work equitably for all users. ### The Teacher-Student Framework * **The Teacher:** A large, powerful pre-trained model (initially StyleGAN2 with StyleCLIP, later transitioning to Google DeepMind’s Imagen) acts as the "expert" that generates high-fidelity visual effects. * **The Student:** A lightweight UNet-based architecture designed for mobile efficiency. It utilizes a MobileNet backbone for both the encoder and decoder to ensure fast frame-by-frame processing. * The distillation process narrows the scope of the massive teacher model into a student model focused on a single, specific task. ### Iterative Distillation and Training * **Data Generation:** The teacher model processes thousands of images to create "before and after" pairs. These are augmented with synthetic elements like AR glasses, sunglasses, and hand occlusions to improve real-world robustness. * **Optimization:** The student model is trained using a sophisticated combination of loss functions, including L1, LPIPS, Adaptive, and Adversarial loss, to balance numerical accuracy with aesthetic quality. * **Architecture Search:** Neural architecture search is employed to tune "depth" and "width" multipliers, identifying the most efficient model structure for different mobile hardware constraints. ### Addressing the Inversion Problem * A major challenge in real-time effects is the "inversion problem," where the model struggles to represent a real face in latent space, leading to a loss of the user's identity (e.g., changes in skin tone or clothing). * YouTube uses Pivotal Tuning Inversion (PTI) to ensure that the user's specific features are preserved during the generative process. * By editing images in the latent space—a compressed numerical representation—the system can apply stylistic changes while maintaining the core characteristics of the original video stream. By combining advanced model distillation with on-device optimization via MediaPipe, YouTube demonstrates a practical path for bringing heavy generative AI research into consumer-facing mobile applications.

Securing private data at scale with differentially private partition selection (opens in new tab)

Google Research has introduced a novel parallel algorithm called MaxAdaptiveDegree (MAD) to enhance differentially private (DP) partition selection, a critical process for identifying common data items in massive datasets without compromising individual privacy. By utilizing an adaptive weighting mechanism, the algorithm optimizes the utility-privacy trade-off, allowing researchers to safely release significantly more data than previous non-adaptive methods. This breakthrough enables privacy-preserving analysis on datasets containing hundreds of billions of items, scaling up to three orders of magnitude larger than existing sequential approaches. ## The Role of DP Partition Selection * DP partition selection identifies a meaningful subset of unique items from large collections based on their frequency across multiple users. * The process ensures that no single individual's data can be identified in the final list by adding controlled noise and filtering out items that are not sufficiently common. * This technique is a foundational step for various machine learning tasks, including extracting n-gram vocabularies for language models, analyzing private data streams, and increasing efficiency in private model fine-tuning. ## The Weight, Noise, and Filter Paradigm * The standard approach to private partition selection begins by computing a "weight" for each item, typically representing its frequency, while ensuring "low sensitivity" so no single user has an outsized impact. * Random Gaussian noise is added to these weights to obfuscate exact counts, preventing attackers from inferring the presence of specific individuals. * A threshold determined by DP parameters is then applied; only items whose noisy weights exceed this threshold are included in the final output. ## Improving Utility via Adaptive Weighting * Traditional non-adaptive methods often result in "wastage," where highly popular items receive significantly more weight than necessary to cross the selection threshold. * The MaxAdaptiveDegree (MAD) algorithm introduces adaptivity by identifying items with excess weight and rerouting that weight to "under-allocated" items sitting just below the threshold. * This strategic reallocation allows a larger number of less-frequent items to be safely released, significantly increasing the utility of the dataset without compromising privacy or computational efficiency. ## Scalability and Parallelization * Unlike sequential algorithms that process data one piece at a time, MAD is designed as a parallel algorithm to handle the scale of modern user-based datasets. * The algorithm can process datasets with hundreds of billions of items by breaking the problem down into smaller parts computed simultaneously across multiple processors. * Google has open-sourced the implementation on GitHub to provide the research community with a tool that maintains robust privacy guarantees even at a massive scale. Researchers and data scientists working with large-scale sensitive datasets should consider implementing the MaxAdaptiveDegree algorithm to maximize the amount of shareable data while strictly adhering to user-level differential privacy standards.

Case study on improving video playback quality (opens in new tab)

Engineers at LINE identified a recurring monthly degradation in video call quality, specifically in Japan, where packet loss increased and frames per second (FPS) dropped toward the end of each month. Investigation revealed that this pattern was caused by mobile ISP bitrate throttling once users exhausted their monthly data caps, which the existing congestion control mechanisms were failing to handle efficiently. To resolve this, the team improved their proprietary CCFS (Congestion Control based on Forward path Status) algorithm to more accurately detect these specific network constraints and maintain stable playback. ### Analysis of Monthly Quality Degradation * Data analysis showed a "monthly cycle" where video decoding FPS was highest at the start of the month and progressively declined toward the end. * This quality drop was specifically tied to an increase in video packet loss, which prevents normal decoding and results in stuttering or frozen frames. * Statistical segmentation revealed the issue occurred almost exclusively on 4G mobile networks rather than Wi-Fi, and was more pronounced in high-bitrate video calls than in voice calls. * The root cause was identified as mobile data plan policies; as users hit their monthly data limits, ISPs impose speed restrictions that create network congestion if the application continues to send high-bitrate data. ### Limitations of Standard Congestion Control * While the IETF RMCAT working group has standardized algorithms like NADA (RFC8698) and SCReAM (RFC8298), real-time two-way communication requires more sensitive response times than one-way streaming. * In two-way calls, even a one-second delay makes natural conversation difficult, meaning the system cannot rely on large buffers to smooth out network instability. * Existing mechanisms were not reacting fast enough to the rigid throughput limits imposed by carrier throttling, leading to packet accumulation in network queues and subsequent loss. ### The CCFS Proprietary Algorithm * LINE utilizes a custom-developed, sender-based algorithm called CCFS (Congestion Control based on Forward path Status). * Unlike older algorithms that rely on Round Trip Time (RTT), CCFS focuses on the "forward path"—the actual path packets take to the receiver—by analyzing feedback on packet arrival times and loss. * CCFS categorizes network status into four distinct states: Default, Probing, Throttled, and Competing. * The system monitors "delay variation"; when it detects a continuous increase in delay exceeding a specific threshold, it transitions to the "Throttled" state to proactively reduce bitrate before the queue overflows. ### Strategies for Quality Improvement * The team focused on refining how CCFS handles the transition into the Throttled state to better align with the artificial bandwidth ceilings created by ISPs. * By improving the sensitivity of forward path status monitoring, the application can more rapidly adjust its transmission rate to stay within the user's current data plan limits. * This technical adaptation ensures that even when a user's mobile speed is restricted, the video remains smooth, albeit at a lower resolution, rather than breaking up due to packet loss. To provide a high-quality communication experience, developers must account for external factors like regional ISP policies. Refining proprietary congestion control algorithms to detect specific patterns, such as monthly data-cap throttling, allows for a more resilient service that maintains stability across diverse mobile environments.

Beyond billion-parameter burdens: Unlocking data synthesis with a conditional generator (opens in new tab)

The CTCL (Data Synthesis with ConTrollability and CLustering) framework provides a lightweight alternative to the computationally expensive process of fine-tuning billion-parameter models for differentially private synthetic data generation. By utilizing a 140-million parameter generator and a universal topic model, the system achieves high-quality distribution matching while remaining accessible for resource-constrained applications. This approach allows for the generation of unlimited synthetic samples without incurring additional privacy costs, consistently outperforming existing API-based and large-scale baselines under strict privacy guarantees. ### Pre-training Universal Components The framework relies on two core components developed using large-scale public corpora, which can be reused across different private domains: * **CTCL-Topic:** A universal topic model derived from Wikipedia documents. It uses BERTopic to embed and cluster data into approximately 1,000 distinct topics, each represented by 10 descriptive keywords. * **CTCL-Generator:** A conditional language model based on the 140M-parameter BART-base architecture. It was pre-trained on 430 million description–document pairs from the SlimPajama dataset, with descriptions generated by Gemma-2-2B to ensure the model can generate text based on specific input conditions. ### Learning the Private Domain Once the universal components are established, the framework learns the specific characteristics of a private dataset through a two-step process: * **Differentially Private (DP) Histograms:** The system captures high-level distributional information by creating a DP-protected histogram that represents the percentage of each topic present in the private corpus. * **DP Fine-Tuning:** Each document in the private dataset is associated with its corresponding keywords from the CTCL-Topic model. The CTCL-Generator is then fine-tuned on these keyword-document pairs using differential privacy to ensure individual data points are protected. ### Controllable Data Generation The final stage involves producing the synthetic dataset by sampling from the fine-tuned generator: * **Proportional Sampling:** The system generates data by targeting the exact topic proportions found in the private domain histogram. * **Keyword Conditioning:** For each topic, the model uses the associated 10 keywords as input to prompt the DP fine-tuned generator to produce relevant documents. * **Post-Processing Efficiency:** Because the generator is already fine-tuned with DP, the framework can generate an unlimited number of synthetic samples without further privacy budget expenditure, a significant advantage over iterative selection algorithms. CTCL offers a highly scalable and efficient solution for organizations needing to synthesize private text data without the infrastructure requirements of massive LLMs. Its ability to maintain topic-wise distribution through keyword conditioning makes it an ideal choice for specialized domains where maintaining the statistical utility of the data is as critical as protecting user privacy.

The Present State of LY Corporation's (opens in new tab)

Tech-Verse 2025 showcased LY Corporation’s strategic shift toward an AI-integrated ecosystem following the merger of LINE and Yahoo Japan. The event focused on the practical hurdles of deploying generative AI, concluding that the transition from experimental models to production-ready services requires sophisticated evaluation frameworks and deep contextual integration into developer workflows. ## AI-Driven Engineering with Ark Developer LY Corporation’s internal "Ark Developer" solution demonstrates how AI can be embedded directly into the software development life cycle. * The system utilizes a Retrieval-Augmented Generation (RAG) based code assistant to handle tasks such as code completion, security reviews, and automated test generation. * Rather than treating codebases as simple text documents, the tool performs graph analysis on directory structures to maintain structural context during code synthesis. * Real-world application includes a seamless integration with GitHub for automated Pull Request (PR) creation, with internal users reporting higher satisfaction compared to off-the-shelf tools like GitHub Copilot. ## Quantifying Quality in Generative AI A significant portion of the technical discussion centered on moving away from subjective "vibes-based" assessments toward rigorous, multi-faceted evaluation of AI outputs. * To measure the quality of generated images, developers utilized traditional metrics like Fréchet Inception Distance (FID) and Inception Score (IS) alongside LAION’s Aesthetic Score. * Advanced evaluation techniques were introduced, including CLIP-IQA, Q-Align, and Visual Question Answering (VQA) based on video-language models to analyze image accuracy. * Technical challenges in image translation and inpainting were highlighted, specifically the difficulty of restoring layout and text structures naturally after optical character recognition (OCR) and translation. ## Global Technical Exchange and Implementation The conference served as a collaborative hub for engineers across Japan, Taiwan, and Korea to discuss the implementation of emerging standards like the Model Context Protocol (MCP). * Sessions emphasized the "how-to" of overcoming deployment hurdles rather than just following technical trends. * Poster sessions (Product Street) and interactive Q&A segments allowed developers to share localized insights on LLM agent performance and agentic workflows. * The recurring theme across diverse teams was that the "evaluation and verification" stage is now the primary driver of quality in generative AI services. For organizations looking to scale AI, the key recommendation is to move beyond simple implementation and invest in "evaluation-driven development." By building internal tools that leverage graph-based context and quantitative metrics like Aesthetic Scores and VQA, teams can ensure that generative outputs meet professional service standards.

Enabling physician-centered oversight for AMIE (opens in new tab)

Guardrailed-AMIE (g-AMIE) is a diagnostic AI framework designed to perform patient history-taking while strictly adhering to safety guardrails that prevent it from providing direct medical advice. By decoupling data collection from clinical decision-making, the system enables an asynchronous oversight model where primary care physicians (PCPs) review and finalize AI-generated medical summaries. In virtual clinical trials, g-AMIE’s diagnostic outputs and patient communications were preferred by overseeing physicians and patient actors over human-led control groups. ## Multi-Agent Architecture and Guardrails * The system utilizes a multi-agent setup powered by Gemini 2.0 Flash, consisting of a dialogue agent, a guardrail agent, and a SOAP note agent. * The dialogue agent conducts history-taking in three distinct phases: general information gathering, targeted validation of a differential diagnosis, and a conclusion phase for patient questions. * A dedicated guardrail agent monitors and rephrases responses in real-time to ensure the AI abstains from sharing individualized diagnoses or treatment plans directly with the patient. * The SOAP note agent employs sequential multi-step generation to separate summarization tasks (Subjective and Objective) from more complex inferential tasks (Assessment and Plan). ## The Clinician Cockpit and Asynchronous Oversight * To facilitate human review, researchers developed the "clinician cockpit," a web interface co-designed with outpatient physicians through semi-structured interviews. * The interface is structured around the standard SOAP note format, presenting the patient’s perspective, measurable data, differential diagnosis, and proposed management strategy. * This framework allows overseeing PCPs to review cases asynchronously, editing the AI’s proposed differential diagnoses and management plans before sharing a final message with the patient. * The separation of history-taking from decision-making ensures that licensed medical professionals retain ultimate accountability for patient care. ## Performance Evaluation via Virtual OSCE * The system was evaluated in a randomized, blinded virtual Objective Structured Clinical Examination (OSCE) involving 60 case scenarios. * g-AMIE’s performance was compared against primary care physicians, nurse practitioners, and physician assistants who were required to operate under the same restrictive guardrails. * Overseeing PCPs and independent physician raters preferred g-AMIE’s diagnostic accuracy and management plans over those of the human control groups. * Patient actors reported a preference for the messages generated by g-AMIE compared to those drafted by human clinicians in the study. While g-AMIE demonstrates high potential for human-AI collaboration in diagnostics, the researchers emphasize that results should be interpreted with caution. The workflow was specifically optimized for AI characteristics, and human clinicians may require specialized training to perform effectively within such highly regulated guardrail frameworks.

Sharing the workflow of a (opens in new tab)

This blog post outlines a structured nine-step workflow designed to enhance development efficiency and improve the code review experience within a collaborative team environment. By emphasizing pre-implementation simulation, task visualization through Jira, and proactive self-feedback, the author demonstrates how breaking work into manageable, reviewer-friendly units leads to more predictable and reliable software delivery. The core conclusion is that prioritizing "reviewability" through small, logical increments fosters team trust and reduces technical debt. ### Strategic Planning and Simulation * Begin by thoroughly reviewing requirements and simulating the feature’s behavior, focusing specifically on data flow, state management, and edge cases. * Proactively communicate with stakeholders to clarify ambiguities and suggest user experience improvements before any code is written. * Draft high-level diagrams or flowcharts to map out how data points interact and where specific logic should reside, ensuring a solid architectural foundation. ### Task Visualization and Collaborative Alignment * Organize features into Jira Epics and decompose them into granular tickets that include estimated effort and dependencies. * Sync with teammates early—specifically between workflow design and ticket creation—to align on technical direction and prevent significant rework during the final review stage. * Ensure ticket titles are concise and descriptive to allow teammates to understand the project's progress at a glance. ### PoC-Driven Iteration and Self-Feedback * Conduct Proof of Concept (PoC) or prototyping to validate assumptions and identify unforeseen technical challenges before committing to a final implementation. * Perform self-feedback by checking the volume of code changes; the author suggests a 400-line threshold, beyond which a ticket should be split into sub-tasks to maintain clarity. * Use tools like `git diff` or temporary PR branches to review your own work from the perspective of a reviewer, identifying parts of the code that may be difficult to digest. ### Implementation and Documentation for Reviewers * Commit code in small, meaningful increments with clear messages, following a logical sequence such as defining interfaces before their actual implementations. * Draft Pull Requests (PRs) using standardized templates that include the purpose of the change, affected features, and developer test results. * Include visual aids, such as videos or screenshots, for complex UI changes or intricate workflows to reduce the cognitive load on the reviewer. ### Future Process Refinement * Improve the accuracy of project timelines by strictly recording actual time spent on tickets compared to original estimates in Jira. * Analyze the delta between "Estimated" and "Actual" time to better understand personal development velocity and refine future scheduling. Adopting this systematic approach helps developers transition from simply "writing code" to managing a complete technical lifecycle. For teams prioritizing code quality, implementing a line-count threshold for PRs and scheduling early-stage technical alignment sessions can significantly reduce "review fatigue" and streamline the path to production.